BOWEL MOTILITY DISORDERS
Colon Transit Markers, Validated Method & Standardized Reporting Tool
Can Assist You in the Assessment and Treatment of Constipation, Diarrhoea and IBS
International experts (Mayo, Gothenburg and others) states that there are two transit methods able to differ between subtypes of functional disorders of the lower gastrointestinal tract and healthy individuals, the Mayo and the Transit-Pellets principle, the latter a study on 359 patients. The authors emphasize that both methods are validated and with respect to radiopaque markers a method with marker ingestion over six days should be preferred.
Slight differences in performing the test exist between laboratories, with one validated method being the ingestion of 10 radiopaque markers per day for six consecutive days, followed by fluoroscopy imaging on the morning of day 7 to count the remaining markers.
The CTT of normal healthy children is not sex- or age-related (above the age of 3 years). The Abrahamson method for CTT measurement by using bony landmarks for the determination of colon segments is easy to perform and well tolerated with a virtual inexistent rating difference between different observers
Investigations of anorectal manometry, endosonography and colonic transit studies provide noninvasive objective assessment of diagnosis and severity of chronic IC and fecal incontinence in children. This information is valuable for the clinician to plan the treatment strategy and for parents and children to understand the underlying pathophysiology.
CTT provides an objective measure to assess childhood constipation. To date, 6 studies using 5 different methods have been published reporting values for healthy children. Comparing these, Abrahamson’s method has low radiation exposure and is well tolerated. This study contributes additional normal values in children.
Illustration of Transit-Pellets marker movement
Validated Method & Safe Colon Transit Markers for the Quantitative Evaluation of Overall & Regional Colonic Transit
The Transit-Pellets method and Transit-Pellets radiopaque markers can be used to:
- Measure rapid, normal and slow colonic transit
- Differentiate between slow transit and normal transit constipation
- Identify segmental colon dysfunction in patients with constipation
- Differentiate between normal and rapid transit diarrhoea
- Identify treatment effects in patients with chronic constipation
A colonic transit test with the Transit-Pellets method, formerly known as the Abrahamsson method, and Transit-Pellets radiopaque markers can quantify the severity of transit problems. The test can be important in determining the need for additional diagnostic procedures, selecting the appropriate therapy, and predicting long-term prognosis. The test results can be used to guide decision-making in these areas.
References can be found in the VALIDATED METHOD section.
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